Current insights intoLMNAcardiomyopathies: Existing models and missing LINCs
نویسندگان
چکیده
منابع مشابه
Current insights into LMNA cardiomyopathies: Existing models and missing LINCs
The nuclear lamina is a critical structural domain for the maintenance of genomic stability and whole-cell mechanics. Mutations in the LMNA gene, which encodes nuclear A-type lamins lead to the disruption of these key cellular functions, resulting in a number of devastating diseases known as laminopathies. Cardiomyopathy is a common laminopathy and is highly penetrant with poor prognosis. To da...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2017
ISSN: 1949-1034,1949-1042
DOI: 10.1080/19491034.2016.1260798